Department of Clinical Physics & Bioengineering (DCPB)

NHS Greater Glasgow & Clyde, Scotland

NHS GGC logo

Research:

Imaging

Lead: Professor Barrie Condon
Head of Imaging Physics
GG&C Health Board, MRI Unit
Institute of Neurological Sciences
Govan Road
Glasgow
G51 4TF
0141-201-2127
barrie.condon@udcf.gla.ac.uk

Primary Areas of Research and contacts:

Functional Magnetic Resonance imaging (fMRI)
Dr. David Brennan 9147261b@clinmed.gla.ac.uk

MRI in Cardiology
Dr. John Foster gcl271@clinmed.gla.ac.uk

MRI in Paediatrics
Dr. John Foster gcl271@clinmed.gla.ac.uk

MR Spectroscopy
Prof. Barrie Condon
barrie.condon@udcf.gla.ac.uk

Pre-clinical MRI and MRS
Prof. Barrie Condon
barrie.condon@udcf.gla.ac.uk
(see also http://www.gla.ac.uk/departments/glasgowexperimentalmricentre/ )

MRI Safety
Prof. Barrie Condon
barrie.condon@udcf.gla.ac.uk

MRI: Brain and hippocampal volumetry, including hippocampal substructures
John McLean
johnmclean@nhs.net

NeuroSPECT
Dr. Alice Nicol
a.nicol@clinmed.gla.ac.uk

Positron Emission Tomography (PET)
Dr. Gerry Gillen
Gerry.Gillen@ggc.scot.nhs.uk

Facilities

DCPB Imaging staff supply physics support to 14 clinical 1.5T MR systems and one clinical 3T system as well as to a 3T research cardiac imaging system at the BHF Glasgow Cardiovascular Research Centre and two 7T pre-clinical systems at the Glasgow Experimental MRI Centre at the University of Glasgow. They also supply clinical and research support to 15 Nuclear Medicine gamma cameras, a PET scanner, a cyclotron, a dedicated NeuroSPECT scanner and two DEXA systems.

Funding:

MRC, Sackler Foundation, Wyeth TMRI, SINAPSE, Neurosciences Foundation, Scottish Enterprise

Full publications since 2005:

Measurement of tumour size in recurrent malignant glioma: 1D, 2D or 3D?. M. Dempsey, B. Condon, D. Hadley. American Journal of Neuroradiology 2005;26:770-776

The relationship between electrical axis by 12-lead electrocardiogram and anatomical axis of the heart by cardiac magnetic resonance in healthy subjects. Engblom H, Foster JE, Martin TN, Groenning B, Pahlm O, Dargie HJ, Wagner GS, Arheden H. Am Heart J. 2005 Sep;150(3):507-12

Contrast enhanced-cardiovascular magnetic resonance imaging in patients with pulmonary hypertension. Blyth KG, Groenning BA, Martin TN, Foster JE, Mark PB, Dargie HJ, Peacock AJ. Eur Heart J. 2005 Oct;26(19):1993-9.

Determination of left ventricular long-axis orientation using MRI: changes during the respiratory and cardiac cycles in normal and diseased subjects. Foster JE, Engblom H, Martin TN, Wagner GS, Steedman T, Ferrua S, Elliott AT, Dargie HJ, Groenning BA. Clin Physiol Funct Imaging. 2005 Sep;25(5):286-92.

The potential of magnetic resonance imaging (MRI) technology in trans-tibial socket research; a pilot study. Buis AWP, Condon B, Brennan D, McHugh B, Hadley D. Journal of Rehabilitation Research and Development 2006;43:883-890

17<beta>-estradiol treatment following permanent focal ischemia does not influence recovery of sensorimotor function. Farr T.,Hilary VO Carswell, PhD; Lindsay Gallagher; Barrie Condon, PhD; Andrew J Fagan, PhD; Jim Mullin; Mhairi I Macrae, PhD. Neurobiology of Disease 2006: 23(3):552-62, 2006 Sep.

Redefinition of uremic cardiomyopathy by contrast-enhanced cardiac magnetic resonance imaging. Mark PB, Johnston N, Groenning BA, Foster JE, Blyth KG, Martin TN, Steedman T, Dargie HJ, Jardine AG. Kidney Int. 2006 May;69(10):1839-45.

Successful antiparkinsonian medication withdrawal in patients with Parkinsonism and normal FP-CIT SPECT. Marshall VL. Patterson J. Hadley DM. Grosset KA. Grosset DG. Movement Disorders. 21(12):2247-50, 2006 Dec.

Assessment of 123I-FIAU imaging of herpes simplex viral gene expression in the treatment of glioma. Dempsey MF. Wyper D. Owens J. Pimlott S. Papanastassiou V. Patterson J. Hadley DM. Nicol A. Rampling R. Brown SM. Nuclear Medicine Communications. 27(8):611-7, 2006 Aug.

Serotonin transporter residual availability during long-term antidepressant therapy does not differentiate responder and nonresponder unipolar patients. Cavanagh J. Patterson J. Pimlott S. Dewar D. Eersels J. Dempsey MF. Wyper D. Biological Psychiatry. 59(4):301-8, 2006 Feb 15.

Two-year follow-up in 150 consecutive cases with normal dopamine transporter imaging. Marshall VL, Patterson J, Hadley DM, Grosset KA, Grosset DG. Nucl Med Commun. 2006 Dec;27(12):933-937.

Non-invasive Monitoring Of Chick Development in ovo using a 7T MRI system from day 12 incubation through to hatching. Maureen M. Bain, Andrew J. Fagan, James M. Mullin, Iain McNaught, John McLean, Barrie Condon, JMRI 2007; 26 (1): 198-201

NT-proBNP can be used to detect right ventricular systolic dysfunction in pulmonary hypertension. Blyth KG, Groenning BA, Mark PB, Martin TN, Foster JE, Steedman T, Morton JJ, Dargie HJ, Peacock AJ. Eur Respir J. 2007 Apr;29(4):737-44.

Vascular function in patients with end-stage renal disease and/or coronary artery disease: a cardiac magnetic resonance imaging study. Zimmerli LU, Mark PB, Steedman T, Foster JE, Berg GA, Dargie HJ, Jardine AG, Delles C, Dominiczak AF. Kidney Int. 2007 Jan;71(1):68-73.

Pulmonary arterial pulse pressure and mortality in pulmonary arterial hypertension. Blyth KG, Syyed R, Chalmers J, Foster JE, Saba T, Naeije R, Melot C, Peacock AJ. Respir Med. 2007 Dec;101(12):2495-501.

ST-segment deviation analysis of the admission 12-lead electro-cardiogram as an aid to early diagnosis of acute myocardial infarction with a cardiac magnetic resonance imaging gold standard. Martin TN, Groenning BA, Murray HM, Steedman T, Foster JE, Elliot AT, Dargie HJ, Selvester RH, Pahlm O, Wagner GS. J Am Coll Cardiol. 2007 Sep 11;50(11):1021-8.

SPECT imaging of the a4b2 nicotinic receptor using [5-123I]A85380. Pimlott S, Piggott M, Patterson J, Cavanagh J, Wyper DJ. J Label Compd Radiopharm 2007; 50: 350?353.

Cholinesterase inhibitor use does not significantly influence the ability of 123I-FP-CIT imaging to distinguish Alzheimer's disease from dementia with Lewy bodies. Taylor JP. Colloby SJ. McKeith IG. Burn DJ. Williams D. Patterson J. O'Brien JT. Journal of Neurology, Neurosurgery & Psychiatry. 78(10):1069-71, 2007 Oct.

Serial Post-mortem Relaxometry in the Normal Rat Brain and Following Stroke. Andrew J. Fagan, J. Mullin, Gallagher L., D. Hadley, I. Macrae, B.Condon. JMRI 2008;27(3):469-475

High resolution 3-D isotropic MR imaging of mouse flank tumours obtained in-vivo with solenoid RF micro-coil. W M Holmes, S Maclellan, B Condon, C Dufès, T R J Evans, I F Uchegbu and A G Schätzlein. Physics in Medicine and 2008;53(2):505-513

Non-Invasive Self-Gated MR Cardiac Imaging of Developing Chick Embryos In-Ovo. William M. Holmes, Christopher McCabe, Jim M. Mullin; Barrie Condon, Maureen M. Bain. Circulation 2008;117(21):e346-7(in press).

Potential use of Oxygen as a metabolic bio-sensor in combination with T2* weighted MRI to define the ischemic penumbra. Celestine Santosh, David Brennan, Christopher McCabe, I.Mhairi Macrae, William M Holmes, David Graham, Lindsay Gallagher, Barrie Condon, Donald M Hadley, Keith Muir, *Willy Gsell. Journal of Cerebral Blood Flow and Metabolism 2008; 28(10): 1742-1753

Cardiac magnetic resonance findings predict increased resource utilization in elective coronary artery bypass grafting. Berry C, Zimmerli LU, Steedman T, Foster JE, Dargie HJ, Berg GA, Dominiczak AF, Delles C. Clin Sci (Lond). 2008 Mar;114(6):423-30.

Aortic stiffness and diastolic flow abnormalities in end-stage renal disease assessed by magnetic resonance imaging. Doyle A, Mark PB, Johnston N, Foster J, Connell JM, Dargie H, Jardine A, Padmanabhan N. Nephron Clin Pract. 2008;109(1):c1-8

Vascular function assessed with cardiovascular magnetic resonance predicts survival in patients with advanced chronic kidney disease. Mark PB, Doyle A, Blyth KG, Patel RK, Weir RA, Steedman T, Foster JE, Dargie HJ, Jardine AG J Cardiovasc Magn. Reson. 2008 Aug 18 ;10(1) :39<

Localisation of regions of intense pleasure response evoked by soccer goals. John McLean, David Brennan, David Wyper, Barrie Condon, Donald Hadley and Jonathan Cavanagh. Psychiatry Research. 171(1):33-43, 2009 Jan 30.

A searchable medical implant database for safety in the medical resonance environment. Macfarlane, J.A., Condon, B. Radiography volume 14, issue 4, year 2008, pp. 362 ? 365

Classification images reveal the information sensitivity of brain voxels in fMRI. Smith FW. Muckli L. Brennan D. Pernet C. Smith ML. Belin P. Gosselin F. Hadley DM. Cavanagh J. Schyns PG. Neuroimage. 40(4):1643-54, 2008 May 1.

alpha4beta2-nicotinic receptor binding with 5-IA in Alzheimer's disease: methods of scan analysis. Terriere E. Sharman M. Donaghey C. Herrmann L. Lonie J. Strachan M. Dougall N. Best J. Ebmeier KP. Pimlott S. Patterson J. Wyper D. Neurochemical Research. 33(4):643-51, 2008 Apr

Evaluation of the Hazards Presented by a Ferromagnetic Orthopaedic Implant in Magnetic Resonance Imaging. Christie McComb, Peter Allen, Barrie Condon. Journal of Magnetic Resonance Imaging. 29(2):449-53, 2009 Feb.

A 3D finite element model of maximal grip loading in the human wrist. Magnus K Gislason, PhD; David H Nash; Alexander Nicol; Asimakis Kanellopoulos; Marc Bransby-Zachary; Tim Hems; Barrie Condon; Benedict Stansfield. Proceedings of the Institution of Mechanical Engineers, Part H, Journal of Engineering in Medicine 2009 223: 849-862

In Ovo Non-Invasive Quantification of Myocardial Function and Mass of Chick Embryos using Magnetic Resonance Imaging, William M. Holmes, Christopher McCabe, Jim M. Mullin, Barrie Condon, Maureen M. Bain NMR in Biomedicine 2009 in press

Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: Procedure development using CaliBrain structural MRI data. T William J Moorhead, Viktoria-Eleni Gountouna, Dominic E Job, Anfrew M McInitosh, Liana Romaniuk, G Katherine S Lymer, Heather C Whalley, Gordon D Waiter, David Brennan, Trevor S Ahearn, Jonathan Cavanagh, Barrie Condon, J Douglas Steele, Joanna M Wardlaw and Stephen M Lawrie. BMC Medical Imaging 2009, 9:8 (15 May 2009)

High resolution micro-SPECT scanning in rats using 125I b-CIT: Effects of chronic treatment with carbamazepine. Cain SM. Ruest T. Pimlott S. Patterson J. Duncan R. Dewar D. Sills GJ. Epilepsia. 50(8):1962-70, 2009 Aug.

Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: a 3-year European multicenter study with repeat [123I]FP-CIT SPECT. Marshall VL. Reininger CB. Marquardt M. Patterson J. Hadley DM. Oertel WH. Benamer HT. Kemp P. Burn D. Tolosa E. Kulisevsky J. Cunha L. Costa D. Booij J. Tatsch K. Chaudhuri KR. Ulm G. Pogarell O. Hoffken H. Gerstner A. Grosset DG.

Accuracy of Parkinson?s Disease Diagnosis in 610 General Practice Patients in the West of Scotland. Newman EJ, MD, Breen K, Patterson J, Hadley DM, Grosset KA, Grosset DG. Movement Disorders Published Online November 2009)

SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the 42 nicotinic acetylcholine receptor [123I]5-I-A85380 ligand: In vivo and in vitro evidence. Cavanagh J, Patterson J, Pimlott S, Wyper D, Dewar D. Synapse 2010: 64, 111-116 (Published online October 2009)

Randomised, Controlled Trial of Insulin for Acute Post-stroke Hyperglycemia Michael McCormick, Donald Hadley, John R McLean, Jennifer A. Macfarlane, Barrie Condon, Keith W Muir Annals of Neurology 2010:in press

T2* Weighted Magnetic Resonance Imaging with Hyperoxia in Acute Ischemic Stroke Krishna A Dani, Celestine Santosh, David Brennan, Christopher McCabe, William M Holmes, Barrie Condon, Donald M Hadley, I.Mhairi Macrae, Martin Shaw, Keith W Muir, Annals of Neurology 2010:in press

Copyright DCPB (NHS GGC) © 2011.